Hair transplant PDRN injection: why is it used?
At Modi Hair Plant, PDRN is applied to the recipient area during hair transplant surgery, and a PDRN injection is also administered the day after surgery taking the recovery status into consideration. PDRN is an ingredient that has been studied in the fields of tissue regeneration and wound healing, and it is used as part of our surgical protocol, taking into account the recovery environment not only of the transplanted hair follicles but also of the surrounding skin tissue.
Have you wondered why PDRN injections are used in hair transplants? In this article, we explain in detail the mechanism of action of PDRN, related research findings, and the reasons Modi Hair Plant uses it as part of its surgical protocol.
Key points
- PDRN is an ingredient studied in the fields of tissue regeneration and wound healing
- Modi Hair Plant has applied it in its surgical protocol since 2020
- Used with consideration for the recovery environment after a hair transplant
- Applied together with various graft survival programs depending on the patient's condition
What is PDRN?
PDRN (Polydeoxyribonucleotide) is a substance composed of DNA fragments extracted from the DNA of salmon or trout.
It was initially studied for the purpose of skin regeneration and wound healing, and its scope of use has since expanded to various fields of tissue regeneration.
Recently it has been widely used in dermatology, plastic surgery, and regenerative medicine, and a great deal of research is being conducted on it as an ingredient that supports tissue recovery.
How does PDRN work?
The representative mechanisms of action of PDRN known to date fall broadly into two categories.
1. Supplying the materials needed for DNA synthesis
PDRN is used as material required in the process by which cells create new DNA (the salvage pathway).
Through this, it is known to support the cellular activity required in the recovery process of damaged tissue.
2. Activation of the adenosine A2A receptor
Recent studies have reported that PDRN may stimulate the adenosine A2A receptor and thereby influence various physiological responses.
In these studies,
- reduction of inflammatory cytokines
- promotion of blood vessel formation
- fibroblast activation
- promotion of tissue recovery
and other related mechanisms have been proposed.
Why is the recovery environment important in a hair transplant?
The success of a hair transplant is not determined simply by transplanting hair follicles.
For transplanted hair follicles to settle in stably,
- blood supply
- tissue recovery
- inflammation management
- skin regeneration environment
and other factors must be considered together.
That is why Modi Hair Plant considers this recovery environment important and applies PDRN as part of its surgical protocol.
Why PDRN is used for graft survival and recovery after a hair transplant
In a hair transplant, thousands of hair follicles are transplanted very densely.
From the patient's perspective, a fuller result can be expected,
but conversely, this can place a considerable burden on the skin tissue.
Taking this into account, Modi Hair Plant
considers it important to manage not only the transplanted hair follicles
but also the surrounding skin environment in which the follicles settle.
One part of that process is PDRN.
For this reason, at Modi Hair Plant PDRN is applied to the recipient area during surgery, and a PDRN injection is also administered the day after surgery while checking the recovery status. This is part of a surgical protocol intended to manage the recovery environment of the surrounding tissue as well as the transplanted hair follicles.
What results have actual studies shown?
To date, there are still not many large-scale clinical studies focusing solely on PDRN in the field of hair transplantation.
However, in other tissue recovery fields such as skin grafting and composite grafting, recovery-related effects of PDRN have been reported through research.
In the reported studies,
- improved survival rate of the graft (grafted tissue)
- promotion of re-epithelialization (wound healing) at graft and surgical sites
- support for blood vessel formation and tissue regeneration
- reduction of inflammatory responses
and other related results were observed.
These studies are not under conditions completely identical to hair transplantation, but they can be regarded as reference material supporting the possibility that PDRN may be helpful for the tissue recovery environment.
References
Squadrito F, Bitto A, Irrera N, et al. Pharmacological Activity and Clinical Use of PDRN. Front Pharmacol. 2017;8:224. doi:10.3389/fphar.2017.00224 (free access)
Valdatta L, Thione A, Mortarino C, et al. Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: a pilot study. Curr Med Res Opin. 2004;20(3):403–408. doi:10.1185/030079904125003116 (PubMed)
Heo J, et al. Effect of Polydeoxyribonucleotide on Chondrocutaneous Composite Grafts Survival. Aesthetic Plast Surg. 2019;43(4):1071–1077. doi:10.1007/s00266-019-01400-x (full text)
The references above are studies evaluating the action of PDRN and its tissue recovery effects in various fields of tissue regeneration, including recovery of skin graft donor sites, composite graft survival, and the pharmacological mechanisms of PDRN. In the field of hair transplantation, the potential for its use is being discussed based on these results.
Modi Hair Plant manages the graft survival environment comprehensively.
Modi Hair Plant does not rely on a single method alone for graft survival.
To create a better recovery environment,
we consider various methods together according to the patient's condition.
For example,
- hair follicle stem cell treatment
- PDRN
- hyperbaric oxygen therapy
- additional treatment according to scalp condition
are applied together,
and the recovery environment is managed from multiple angles.
In other words,
rather than looking only at the hair follicle itself,
our goal is to create an environment in which the hair follicles and the surrounding tissue can recover together.
We have been applying it consistently since 2020.
Modi Hair Plant has included and applied PDRN in its hair transplant surgical protocol since 2020. In addition to applying PDRN to the recipient area during surgery, a PDRN injection is also administered the day after surgery to manage the recovery process. The method of application may vary depending on the patient's condition, but we have continued this to date as one of our efforts to create a more stable recovery environment.
What Modi Hair Plant considers important is the 'recovery environment'.
A hair transplant is not simply a surgery of implanting many hair follicles.
The process of creating an environment in which the transplanted hair follicles can settle in stably
and the surrounding tissue can recover healthily is also important.
That is why Modi Hair Plant
considers various elements together, including
a hair follicle sorting system,
customized hair follicle sorting containers,
PDRN,
hair follicle stem cells,
and hyperbaric oxygen therapy,
and continues to conduct research
for better surgical outcomes.
Frequently Asked Questions (FAQ)
Q. Is PDRN used in all hair transplant surgeries?
At Modi Hair Plant it is applied as part of the surgical protocol, and various recovery programs are applied together taking into account the degree of the patient's hair loss progression and scalp condition.
Q. Is PDRN a stem cell?
No. PDRN is not a stem cell but an ingredient related to tissue regeneration that is composed of DNA fragments.
Q. Does hair grow with PDRN alone?
PDRN is not a drug that directly treats hair loss; it is an ingredient used to support the tissue recovery environment.
Q. When is PDRN injected?
At Modi Hair Plant, PDRN is applied to the recipient area during hair transplant surgery, and a PDRN injection is also administered the day after surgery.
This is part of a surgical protocol intended to manage the recovery environment of the surrounding skin tissue as well as the transplanted hair follicles. The method of application is determined and carried out by the medical staff according to the patient's condition and surgical plan.
Q. Do I need additional PDRN injections after a hair transplant?
At Modi Hair Plant, PDRN is applied during surgery as standard, and a PDRN injection is also administered the day after surgery.
Whether additional PDRN treatment is needed thereafter is determined individually by the medical staff after checking the patient's recovery status and scalp condition. If necessary, we will provide guidance on a customized management plan together with other recovery programs.
Conclusion
Modi Hair Plant believes that the surgery does not end with 'implanting the hair follicles well'; creating an environment in which the follicles can settle in stably is also part of the surgery.
The PDRN applied during the hair transplant process is likewise used based on this philosophy, and we continually review a wide range of research on tissue recovery and regeneration as we develop treatment protocols that can be helpful to our patients.
🔻The PDRN surgical protocol explained by Director Yoo Hwa-jung herself
This content was published after review by the medical staff of Modi Hair Plant Clinic.