Hair transplant PDRN injection: Why do we use it?
At Modi Hair Plant Clinic, PDRN is applied to the recipient area during hair transplant surgery, and considering the recovery condition, a PDRN injection is also administered on the day after surgery. PDRN is an ingredient that has been studied in the fields of tissue regeneration and wound recovery, and it is used as one part of the surgical protocol that considers the recovery environment not only of the transplanted hair follicles but also of the surrounding skin tissue.
Have you ever wondered why a PDRN injection is used during a hair transplant? In this article, we explain in detail the mechanism of action of PDRN, related research findings, and the reasons Modi Hair Plant Clinic uses it as part of the surgical protocol.
Key points
- PDRN is an ingredient studied in the fields of tissue regeneration and wound recovery
- Modi Hair Plant Clinic has applied it in its surgical protocol since 2020
- Used with consideration for the recovery environment after a hair transplant
- Applied together with various engraftment programs depending on the patient's condition
What is PDRN?
PDRN (Polydeoxyribonucleotide) is a substance composed of DNA fragments extracted from the DNA of salmon or trout.
It was initially studied for the purpose of skin regeneration and wound recovery, and its scope of use later expanded into various tissue regeneration fields.
More recently, it has been widely used in dermatology, plastic surgery, and regenerative medicine, and much research is being conducted on it as an ingredient that supports tissue recovery.
How does PDRN work?
The representative mechanisms of action of PDRN known to date are largely twofold.
1. Supplying the materials needed for DNA synthesis
PDRN is used as a material needed for the process by which cells create new DNA (the Salvage Pathway).
Through this, it is known to support the cellular activity needed for the recovery process of damaged tissue.
2. Activation of the adenosine A2A receptor
Recent studies have reported that PDRN may stimulate the adenosine A2A receptor and influence various physiological responses.
In research,
- reduction of inflammatory cytokines
- promotion of angiogenesis
- activation of fibroblasts
- promotion of tissue recovery
and related mechanisms have been proposed.
Why is the recovery environment important in a hair transplant?
The success of a hair transplant is not determined simply by transplanting the hair follicles.
For transplanted hair follicles to settle in stably,
- blood supply
- tissue recovery
- inflammation management
- skin regeneration environment
and other factors must be considered together.
That is why Modi Hair Plant Clinic considers this recovery environment important and applies PDRN as one part of its surgical protocol.
The reason PDRN is used for hair transplant engraftment and recovery
In a hair transplant, thousands of hair follicles are transplanted very densely.
From the patient's perspective, a fuller result can be expected,
but conversely, it can also place a considerable burden on the skin tissue.
At Modi Hair Plant Clinic, taking this into account,
we consider it important to manage not only the transplanted hair follicles
but also the surrounding skin environment where the hair follicles settle.
One part of that process is precisely PDRN.
For this reason, at Modi Hair Plant Clinic PDRN is applied to the recipient area during surgery, and a PDRN injection is also administered on the day after surgery while checking the recovery condition. This is part of a surgical protocol to manage the recovery environment not only of the transplanted hair follicles but also of the surrounding tissue.
What results have there been in actual studies?
Currently, there are not yet many large-scale clinical studies targeting PDRN alone in the field of hair transplantation.
However, in other tissue recovery fields such as skin grafts and composite grafts, PDRN's recovery-related effects have been reported through research.
In the reported studies,
- improvement in the survival rate of grafts (transplanted tissue)
- promotion of re-epithelialization (wound recovery) of the graft/surgical site
- support of angiogenesis and tissue regeneration
- reduction of inflammatory responses
and related results were observed.
These studies are not under exactly the same conditions as a hair transplant, but they can be regarded as reference material supporting the possibility that PDRN may help the tissue recovery environment.
References
Squadrito F, Bitto A, Irrera N, et al. Pharmacological Activity and Clinical Use of PDRN. Front Pharmacol. 2017;8:224. doi:10.3389/fphar.2017.00224 (free access)
Valdatta L, Thione A, Mortarino C, et al. Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: a pilot study. Curr Med Res Opin. 2004;20(3):403–408. doi:10.1185/030079904125003116 (PubMed)
Heo J, et al. Effect of Polydeoxyribonucleotide on Chondrocutaneous Composite Grafts Survival. Aesthetic Plast Surg. 2019;43(4):1071–1077. doi:10.1007/s00266-019-01400-x (full text)
The references above are studies that evaluated the action and tissue recovery effects of PDRN in various tissue regeneration fields, including skin graft donor site recovery, composite graft survival, and the pharmacological mechanism of PDRN. In the field of hair transplantation, its potential applicability is being discussed based on these results.
Modi Hair Plant Clinic manages the engraftment environment comprehensively.
Modi Hair Plant Clinic does not rely on a single method alone for engraftment.
To create a better recovery environment,
we consider various methods together depending on the patient's condition.
For example,
- hair follicle stem cell treatment
- PDRN
- hyperbaric oxygen therapy
- additional treatment according to the scalp condition
are applied together,
and we manage the recovery environment from multiple angles.
In other words,
rather than looking at the hair follicle alone,
we aim to create an environment where the hair follicle and the surrounding tissue can recover together.
We have been applying it consistently since 2020.
Modi Hair Plant Clinic has been including and applying PDRN in its hair transplant surgical protocol since 2020. In addition to applying PDRN to the recipient area during surgery, we also administer a PDRN injection on the day after surgery to manage the recovery process. The application method may vary depending on the patient's condition, but it has continued to this day as one of our efforts to create a more stable recovery environment.
What Modi Hair Plant Clinic considers important is the 'recovery environment'.
A hair transplant is not simply a surgery of planting many hair follicles.
The process of creating an environment in which the transplanted hair follicles settle in stably
and the surrounding tissue can recover healthily is also important.
That is why Modi Hair Plant Clinic
considers various factors together, including
a hair follicle sorting system,
customized hair follicle sorting containers,
PDRN,
hair follicle stem cells,
and hyperbaric oxygen therapy,
and continuously conducts research for better surgical results.
Frequently Asked Questions (FAQ)
Q. Is PDRN used in all hair transplant surgeries?
At Modi Hair Plant Clinic, it is applied as one part of the surgical protocol, and various recovery programs are applied together, taking into account the patient's degree of hair loss progression and scalp condition.
Q. Is PDRN a stem cell?
No. PDRN is not a stem cell but a tissue regeneration-related ingredient composed of DNA fragments.
Q. Does hair grow with PDRN alone?
PDRN is not a medication that directly treats hair loss, but an ingredient used to help the tissue recovery environment.
Q. When is PDRN injected?
At Modi Hair Plant Clinic, PDRN is applied to the recipient area during hair transplant surgery, and a PDRN injection is also administered on the day after surgery.
This is one part of the surgical protocol to manage the recovery environment not only of the transplanted hair follicles but also of the surrounding skin tissue. The application method is determined and carried out by the medical staff according to the patient's condition and surgical plan.
Q. Do I need to receive additional PDRN after the hair transplant?
At Modi Hair Plant Clinic, PDRN is basically applied during surgery, and a PDRN injection is also administered on the day after surgery.
Whether additional PDRN treatment is needed thereafter is judged individually by the medical staff after checking the patient's recovery condition and scalp condition. When necessary, we provide a customized management plan together with other recovery programs.
Conclusion
Modi Hair Plant Clinic believes that the surgery does not end with 'planting the hair follicles well,' but that creating an environment in which the hair follicles can settle in stably is also part of the surgery.
The PDRN applied during the hair transplant process is also used based on this philosophy, and we continuously review various studies on tissue recovery and regeneration and develop treatment protocols that can be helpful to our patients.
🔻The PDRN surgical protocol explained directly by Director Yoo Hwa-jung
This content has been posted after review by the medical staff of Modi Hair Plant Clinic.