Hair transplant PDRN injection: why do we use it?
At Modi Hair Plant Clinic, PDRN is applied to the transplant area during hair transplant surgery, and a PDRN injection is also administered the day after surgery in consideration of the recovery condition. PDRN is a component that has been studied in the fields of tissue regeneration and wound recovery, and it is used as part of our surgical protocol that considers the recovery environment not only of the transplanted hair follicles but also of the surrounding skin tissue.
Have you ever wondered why PDRN injections are used during hair transplants? In this article, we explain in detail PDRN's mechanism of action, related research findings, and the reasons Modi Hair Plant Clinic uses it as part of the surgical protocol.
Key points
- PDRN is a component studied in the fields of tissue regeneration and wound recovery
- Modi Hair Plant Clinic has applied it to its surgical protocol since 2020
- Used in consideration of the recovery environment after hair transplant
- Applied together with various graft-survival programs according to the patient's condition
What is PDRN?
PDRN (Polydeoxyribonucleotide) is a substance composed of DNA fragments extracted from the DNA of salmon or trout.
It was initially studied for the purpose of skin regeneration and wound recovery, and its scope of application later expanded into various fields of tissue regeneration.
Recently, it has been widely used in dermatology, plastic surgery, and regenerative medicine, and much research is being conducted on it as a component that aids tissue recovery.
How does PDRN work?
There are broadly two representative mechanisms of action of PDRN known to date.
1. Supplying materials needed for DNA synthesis
PDRN is used as a material needed in the process by which cells create new DNA (the Salvage Pathway).
Through this, it is known to support the cellular activity needed in the recovery process of damaged tissue.
2. Activation of the adenosine A2A receptor
Recent studies have reported that PDRN may stimulate the adenosine A2A receptor, thereby affecting various physiological responses.
In research, mechanisms related to
- reduction of inflammatory cytokines
- promotion of angiogenesis
- fibroblast activation
- promotion of tissue recovery
have been proposed.
Why is the recovery environment important in hair transplant?
The success of a hair transplant is not determined simply by transplanting hair follicles.
For transplanted hair follicles to settle stably,
- blood supply
- tissue recovery
- inflammation management
- skin regeneration environment
and other factors must be considered together.
That is why Modi Hair Plant Clinic considers this recovery environment important and applies PDRN as part of its surgical protocol.
Reasons for using PDRN for hair transplant graft survival and recovery
In hair transplants, thousands of hair follicles are transplanted very densely.
From the patient's perspective, a fuller result can be expected,
but conversely, it can place a considerable burden on the skin tissue.
Taking this into account, Modi Hair Plant Clinic
considers it important to manage not only the transplanted hair follicles
but also the surrounding skin environment where the hair follicles settle.
One part of that process is PDRN.
For these reasons, Modi Hair Plant Clinic applies PDRN to the transplant area during surgery and also administers a PDRN injection the following day while checking the recovery condition. This is part of a surgical protocol designed to manage the recovery environment of not only the transplanted hair follicles but also the surrounding tissue.
What results have been found in actual research?
At present, there are not yet many large-scale clinical studies focusing solely on PDRN in the field of hair transplant.
However, in other tissue-recovery fields such as skin grafts and composite grafts, PDRN's recovery-related effects have been reported through research.
In the reported studies,
- improvement in the survival rate of grafts (grafted tissue)
- promotion of re-epithelialization (wound recovery) at graft/surgical sites
- support for angiogenesis and tissue regeneration
- reduction of inflammatory responses
and other related results were observed.
These studies are not under completely identical conditions to hair transplant, but they can be regarded as reference material supporting the possibility that PDRN may be helpful for the tissue recovery environment.
References
Squadrito F, Bitto A, Irrera N, et al. Pharmacological Activity and Clinical Use of PDRN. Front Pharmacol. 2017;8:224.
Valdatta L, Thione A, Mortarino C, et al. Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: a pilot study. Curr Med Res Opin. 2004;20(3):403–408.
Heo J, et al. Effect of Polydeoxyribonucleotide on Chondrocutaneous Composite Grafts Survival. Aesthetic Plast Surg. 2019. (doi:10.1007/s00266-019-01400-x)
The references above are studies that evaluated the action and tissue-recovery effects of PDRN in various tissue regeneration fields, such as recovery of skin graft donor sites, composite graft survival, and the pharmacological mechanisms of PDRN. In the field of hair transplant, the possibility of its use is being discussed based on these results.
Modi Hair Plant Clinic comprehensively manages the graft-survival environment.
Modi Hair Plant Clinic does not expect graft survival from a single method alone.
To create a better recovery environment,
we consider various methods together according to the patient's condition.
For example,
- hair follicle stem cell treatment
- PDRN
- hyperbaric oxygen therapy
- additional treatment depending on scalp condition
are applied together,
and the recovery environment is managed from multiple angles.
In other words,
rather than looking at the hair follicle alone,
our goal is to create an environment where the hair follicle and surrounding tissue can recover together.
We have consistently applied it since 2020.
Modi Hair Plant Clinic has included and applied PDRN in its hair transplant surgical protocol since 2020. In addition to applying PDRN to the transplant area during surgery, we also administer a PDRN injection the day after surgery and manage the recovery process. The method of application may vary depending on the patient's condition, but we have continued it to this day as one of our efforts to create a more stable recovery environment.
What Modi Hair Plant Clinic considers important is the 'recovery environment.'
A hair transplant is not simply surgery to implant many hair follicles.
The process of creating an environment where the transplanted hair follicles settle stably
and the surrounding tissue can recover healthily is also important.
That is why Modi Hair Plant Clinic
considers various factors together, including
a hair follicle sorting system,
customized hair follicle sorting containers,
PDRN,
hair follicle stem cells,
and hyperbaric oxygen therapy,
and continuously conducts research for better surgical results.
Frequently Asked Questions (FAQ)
Q. Is PDRN used in all hair transplant surgeries?
At Modi Hair Plant Clinic, it is applied as part of the surgical protocol, and various recovery programs are applied together in consideration of the patient's degree of hair loss progression and scalp condition.
Q. Is PDRN a stem cell?
No. PDRN is not a stem cell but a tissue-regeneration-related component composed of DNA fragments.
Q. Does hair grow with PDRN alone?
PDRN is not a drug that directly treats hair loss, but a component used to help the tissue recovery environment.
Q. When is PDRN injected?
At Modi Hair Plant Clinic, PDRN is applied to the transplant area during hair transplant surgery, and a PDRN injection is also administered the day after surgery.
This is part of a surgical protocol to manage the recovery environment of not only the transplanted hair follicles but also the surrounding skin tissue. The method of application is determined and carried out by the medical staff according to the patient's condition and surgical plan.
Q. Do I need to receive additional PDRN even after the hair transplant?
At Modi Hair Plant Clinic, PDRN is basically applied during surgery, and a PDRN injection is also administered the day after surgery.
Whether additional PDRN treatment is subsequently needed is determined individually by the medical staff after checking the patient's recovery condition and scalp condition. If necessary, a customized management plan together with other recovery programs will be provided.
Conclusion
Modi Hair Plant Clinic considers that surgery does not end with 'implanting the hair follicles well,' but also includes creating an environment in which the hair follicles can settle stably.
The PDRN applied during the hair transplant process is also used based on this philosophy, and we continuously review various studies on tissue recovery and regeneration while developing treatment protocols that can be helpful to our patients.
🔻The PDRN surgical protocol explained directly by Director Yoo Hwa-jung
This content was posted after review by the medical staff of Modi Hair Plant Clinic.